Positive Allosteric Modulation of CB(1) Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However, their use can result in a number of unwanted side-effects including incomplete efficacy, constipation, physical dependence, and overdose liability. Cannabinoids enhanc...

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Pubblicato in:Front Mol Neurosci
Autori principali: Slivicki, Richard A., Iyer, Vishakh, Mali, Sonali S., Garai, Sumanta, Thakur, Ganesh A., Crystal, Jonathon D., Hohmann, Andrea G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199816/
https://ncbi.nlm.nih.gov/pubmed/32410959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00054
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