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Positive Allosteric Modulation of CB(1) Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward
Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However, their use can result in a number of unwanted side-effects including incomplete efficacy, constipation, physical dependence, and overdose liability. Cannabinoids enhanc...
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| Publicat a: | Front Mol Neurosci |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7199816/ https://ncbi.nlm.nih.gov/pubmed/32410959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00054 |
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