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Impact of 1,N(6)-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair

Incorporation of ribonucleotides into DNA can severely diminish genome integrity. However, how ribonucleotides instigate DNA damage is poorly understood. In DNA, they can promote replication stress and genomic instability and have been implicated in several diseases. We report here the impact of the...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Ghodke, Pratibha P., Guengerich, F. Peter
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196658/
https://ncbi.nlm.nih.gov/pubmed/32213600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012829
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