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Enzymatic bypass of an N(6)-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases
Unrepaired DNA–protein cross-links, due to their bulky nature, can stall replication forks and result in genome instability. Large DNA–protein cross-links can be cleaved into DNA–peptide cross-links, but the extent to which these smaller fragments disrupt normal replication is not clear. Ethylene di...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8024977/ https://ncbi.nlm.nih.gov/pubmed/33617883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100444 |
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