Enzymatic bypass of an N(6)-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases

Unrepaired DNA–protein cross-links, due to their bulky nature, can stall replication forks and result in genome instability. Large DNA–protein cross-links can be cleaved into DNA–peptide cross-links, but the extent to which these smaller fragments disrupt normal replication is not clear. Ethylene di...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ghodke, Pratibha P., Gonzalez-Vasquez, Gabriela, Wang, Hui, Johnson, Kevin M., Sedgeman, Carl A., Guengerich, F. Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024977/
https://ncbi.nlm.nih.gov/pubmed/33617883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100444
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