Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N(6)-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η

1,N(6)-Ethenodeoxyadenosine (1,N(6)-ϵdA) is the major etheno lesion formed in the reaction of DNA with epoxides substituted with good leaving groups (e.g. vinyl chloride epoxide). This lesion is also formed endogenously in DNA from lipid oxidation. Recombinant human DNA polymerase η (hpol η) can rep...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Patra, Amritraj, Su, Yan, Zhang, Qianqian, Johnson, Kevin M., Guengerich, F. Peter, Egli, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933172/
https://ncbi.nlm.nih.gov/pubmed/27226627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732487
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