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Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N(6)-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η
1,N(6)-Ethenodeoxyadenosine (1,N(6)-ϵdA) is the major etheno lesion formed in the reaction of DNA with epoxides substituted with good leaving groups (e.g. vinyl chloride epoxide). This lesion is also formed endogenously in DNA from lipid oxidation. Recombinant human DNA polymerase η (hpol η) can rep...
Gorde:
| Argitaratua izan da: | J Biol Chem |
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| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4933172/ https://ncbi.nlm.nih.gov/pubmed/27226627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732487 |
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