Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N(6)-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η

1,N(6)-Ethenodeoxyadenosine (1,N(6)-ϵdA) is the major etheno lesion formed in the reaction of DNA with epoxides substituted with good leaving groups (e.g. vinyl chloride epoxide). This lesion is also formed endogenously in DNA from lipid oxidation. Recombinant human DNA polymerase η (hpol η) can rep...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Patra, Amritraj, Su, Yan, Zhang, Qianqian, Johnson, Kevin M., Guengerich, F. Peter, Egli, Martin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933172/
https://ncbi.nlm.nih.gov/pubmed/27226627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.732487
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items