Proteomic analysis of CSF from patients with leptomeningeal melanoma metastases identifies signatures associated with disease progression and therapeutic resistance

PURPOSE: The development of leptomeningeal melanoma metastases (LMM) is a rare and devastating complication of the late-stage disease, for which no effective treatments exist. Here, we performed a multi-omics analysis of the CSF from LMM patients to determine how the leptomeningeal microenvironment...

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Pubblicato in:Clin Cancer Res
Autori principali: Smalley, Inna, Law, Vincent, Wyatt, Clayton, Evernden, Brittany R., Fang, Bin, Koomen, John M., Welsh, Eric, Macaulay, Robert, Forsyth, Peter A., Smalley, Keiran S.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196498/
https://ncbi.nlm.nih.gov/pubmed/31924735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2840
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