Single cell characterization of the immune microenvironment of melanoma brain and leptomeningeal metastases

PURPOSE: Melanoma brain metastases (MBM) and leptomeningeal metastases (LMM) are two different manifestations of melanoma CNS metastasis. Here, we used single cell RNA-Seq (scRNA-Seq) to define the immune landscape of MBM, LMM and melanoma skin metastases. EXPERIMENTAL DESIGN: Single cell RNA-sequen...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Smalley, Inna, Chen, Zhihua, Phadke, Manali, Li, Jiannong, Yu, Xiaoqing, Wyatt, Clayton, Evernden, Brittany, Messina, Jane L., Sarnaik, Amod, Sondak, Vernon K., Zhang, Chaomei, Law, Vincent, Tran, Nam, Etame, Arnold, Macaulay, Robert J.B., Eroglu, Zeynep, Forsyth, Peter A., Rodriguez, Paulo C., Chen, Y. Ann, Smalley, Keiran S.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282775/
https://ncbi.nlm.nih.gov/pubmed/34035069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-21-1694
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