Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling

Protein kinase C-θ (PKCθ) is an important component of proximal T cell receptor (TCR) signaling. We previously identified the amino-terminal C2 domain of PKCθ as a phosphotyrosine (pTyr)-binding domain. Using a mutant form of PKCθ that cannot bind pTyr (PKCθ(HR2A)), we show that pTyr binding by PKCθ...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Xie, Jiji, Han, Xuemei, Zhao, Chensi, Canonigo-Balancio, Ann J., Yates, John R., Li, Yingqiu, Lillemeier, Björn F., Altman, Amnon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195849/
https://ncbi.nlm.nih.gov/pubmed/30992398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aar3349
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