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A novel motif in the V3 domain of PKC-θ determines its immunological synapse localization and functions in T cells via association with CD28
Protein kinase C-θ (PKC-θ) translocates to the center of the immunological synapse, but the underlying mechanism and its importance in T cell activation are unknown. We found that the PKC-θ V3 domain is necessary and sufficient for IS localization mediated by Lck-dependent association with CD28. We...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197934/ https://ncbi.nlm.nih.gov/pubmed/21964608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2120 |
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