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Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling
Protein kinase C-θ (PKCθ) is an important component of proximal T cell receptor (TCR) signaling. We previously identified the amino-terminal C2 domain of PKCθ as a phosphotyrosine (pTyr)-binding domain. Using a mutant form of PKCθ that cannot bind pTyr (PKCθ(HR2A)), we show that pTyr binding by PKCθ...
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| Publicat a: | Sci Signal |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7195849/ https://ncbi.nlm.nih.gov/pubmed/30992398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aar3349 |
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