SPAK kinase is a substrate and target of PKCθ in T-cell receptor-induced AP-1 activation pathway

Protein kinase C-θ (PKCθ) plays an important role in T-cell activation via stimulation of AP-1 and NF-κB. Here we report the isolation of SPAK, a Ste20-related upstream mitogen-activated protein kinase (MAPK), as a PKCθ-interacting kinase. SPAK interacted with PKCθ (but not with PKCα) via its 99 COO...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Yingqiu, Hu, Junru, Vita, Randi, Sun, Binggang, Tabata, Hiroki, Altman, Amnon
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2004
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC380980/
https://ncbi.nlm.nih.gov/pubmed/14988727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600125
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