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SPAK kinase is a substrate and target of PKCθ in T-cell receptor-induced AP-1 activation pathway
Protein kinase C-θ (PKCθ) plays an important role in T-cell activation via stimulation of AP-1 and NF-κB. Here we report the isolation of SPAK, a Ste20-related upstream mitogen-activated protein kinase (MAPK), as a PKCθ-interacting kinase. SPAK interacted with PKCθ (but not with PKCα) via its 99 COO...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC380980/ https://ncbi.nlm.nih.gov/pubmed/14988727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600125 |
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