Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C

PKCθ plays an essential role in activation of mature T cells via stimulation of AP-1 and NF-κB, and is known to selectively translocate to the immunological synapse in antigen-stimulated T cells. Recently, we reported that a Vav/Rac pathway which depends on actin cytoskeleton reorganization mediates...

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Detalhes bibliográficos
Main Authors: Villalba, Martin, Bi, Kun, Hu, Junru, Altman, Yoav, Bushway, Paul, Reits, Eric, Neefjes, Jacques, Baier, Gottfried, Abraham, Robert T., Altman, Amnon
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199257/
https://ncbi.nlm.nih.gov/pubmed/11956228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200201097
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