Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY6A receptor on brain endothelial cells. Here, we c...

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Publicado en:Nat Commun
Main Authors: Seo, Jai Woong, Ingham, Elizabeth S., Mahakian, Lisa, Tumbale, Spencer, Wu, Bo, Aghevlian, Sadaf, Shams, Shahin, Baikoghli, Mo, Jain, Poorva, Ding, Xiaozhe, Goeden, Nick, Dobreva, Tatyana, Flytzanis, Nicholas C., Chavez, Michael, Singhal, Kratika, Leib, Ryan, James, Michelle L., Segal, David J., Cheng, R. Holland, Silva, Eduardo A., Gradinaru, Viviana, Ferrara, Katherine W.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193641/
https://ncbi.nlm.nih.gov/pubmed/32355221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15818-4
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