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Regulatory and Exhausted T Cell Responses to AAV Capsid

Recombinant adeno-associated viruses (AAVs) are quickly becoming the preferred viral vector for viral gene delivery for the treatment of a wide variety of genetic disorders. However, since their use in a clinical trial targeting hemophilia B patients 10 years ago, immune responses to the AAV capsid...

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Bibliographic Details
Published in:Hum Gene Ther
Main Authors: Gernoux, Gwladys, Wilson, James M., Mueller, Christian
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399736/
https://ncbi.nlm.nih.gov/pubmed/28323492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.022
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