Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation

Adeno-associated viruses (AAVs) are typically single-stranded deoxyribonucleic acid (ssDNA) encapsulated within 25-nm protein capsids. Recently, tissue-specific AAV capsids (e.g. PHP.eB) have been shown to enhance brain delivery in rodents via the LY6A receptor on brain endothelial cells. Here, we c...

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Vydáno v:Nat Commun
Hlavní autoři: Seo, Jai Woong, Ingham, Elizabeth S., Mahakian, Lisa, Tumbale, Spencer, Wu, Bo, Aghevlian, Sadaf, Shams, Shahin, Baikoghli, Mo, Jain, Poorva, Ding, Xiaozhe, Goeden, Nick, Dobreva, Tatyana, Flytzanis, Nicholas C., Chavez, Michael, Singhal, Kratika, Leib, Ryan, James, Michelle L., Segal, David J., Cheng, R. Holland, Silva, Eduardo A., Gradinaru, Viviana, Ferrara, Katherine W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193641/
https://ncbi.nlm.nih.gov/pubmed/32355221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15818-4
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