Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

Beta-propeller protein-associated neurodegeneration is a subtype of monogenic neurodegeneration with brain iron accumulation caused by de novo mutations in WDR45. The WDR45 protein functions as a beta-propeller scaffold and plays a putative role in autophagy through its interaction with phospholipid...

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Detalles Bibliográficos
Publicado en:Brain
Main Authors: Seibler, Philip, Burbulla, Lena F, Dulovic, Marija, Zittel, Simone, Heine, Johanne, Schmidt, Thomas, Rudolph, Franziska, Westenberger, Ana, Rakovic, Aleksandar, Münchau, Alexander, Krainc, Dimitri, Klein, Christine
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190033/
https://ncbi.nlm.nih.gov/pubmed/30169597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy230
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