C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesis

GGGGCC repeat expansion in C9orf72 is the most common genetic cause in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two neurodegenerative disorders in association with aging. Bidirectional repeat expansions in the noncoding region of C9orf72 have been shown to produce...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Wang, Mingmei, Wang, Hongfeng, Tao, Zhouteng, Xia, Qin, Hao, Zongbing, Prehn, Jochen H. M., Zhen, Xuechu, Wang, Guanghui, Ying, Zheng
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189992/
https://ncbi.nlm.nih.gov/pubmed/32100453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13126
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