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eIF2B and the Integrated Stress Response: a structural and mechanistic view
The eukaryotic translation initiation factor eIF2 is a GTPase, which brings the initiator Met-tRNA(i) to the ribosome as the eIF2-GTP•Met-tRNA(i) ternary complex (TC). TC regeneration is catalyzed by the guanine nucleotide exchange factor (GEF) eIF2B. eIF2 phosphorylation by several stress-induced k...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189779/ https://ncbi.nlm.nih.gov/pubmed/32200625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00132 |
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