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eIF2B Mechanisms of Action and Regulation: A Thermodynamic View

Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor of the GTPase eIF2, which brings the initiator Met-tRNA(i) to the ribosome in the form of the eIF2-GTP·Met-tRNA(i) ternary complex (TC). The activity of eIF2B is inhibited by phosphorylation of its substrat...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Bogorad, Andrew M., Lin, Kai Ying, Marintchev, Assen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840040/
https://ncbi.nlm.nih.gov/pubmed/29425030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00957
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