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Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, which plays a critical role in protein synthesis regulation. eIF2-GTP binds Met-tRNA(i) to form the eIF2-GTP•Met-tRNA(i) ternary complex (TC), which is recruited to the 40S ribosomal subunit. Following GTP hydrolysis, eIF2...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5714165/ https://ncbi.nlm.nih.gov/pubmed/29036434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx845 |
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