Structural basis of eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a GTPase, that becomes activated by eIF2B, a two-fold symmetric and heterodecameric complex that functions as eIF2’s dedicated nu...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Kenner, Lillian R., Anand, Aditya A., Nguyen, Henry C., Myasnikov, Alexander G., Klose, Carolin J., McGeever, Lea A., Tsai, Jordan C., Miller-Vedam, Lakshmi E., Walter, Peter, Frost, Adam
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601628/
https://ncbi.nlm.nih.gov/pubmed/31048491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw2922
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