Structural basis of eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response

The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a GTPase, that becomes activated by eIF2B, a two-fold symmetric and heterodecameric complex that functions as eIF2’s dedicated nu...

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Pubblicato in:Science
Autori principali: Kenner, Lillian R., Anand, Aditya A., Nguyen, Henry C., Myasnikov, Alexander G., Klose, Carolin J., McGeever, Lea A., Tsai, Jordan C., Miller-Vedam, Lakshmi E., Walter, Peter, Frost, Adam
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601628/
https://ncbi.nlm.nih.gov/pubmed/31048491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw2922
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