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TLR4-mediated pyroptosis in human hepatoma-derived HuH-7 cells induced by a branched-chain polyunsaturated fatty acid, geranylgeranoic acid

A branched-chain polyunsaturated fatty acid, geranylgeranoic acid (GGA; C(20:4)), which is an endogenous metabolite derived from the mevalonate pathway in mammals, has been reported to induce cell death in human hepatoma cells. We have previously shown that the lipid-induced unfolded protein respons...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Yabuta, Suemi, Shidoji, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7189495/
https://ncbi.nlm.nih.gov/pubmed/32270855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20194118
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