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Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells

The acyclic diterpenoid acid geranylgeranoic acid (GGA) has been reported to induce autophagic cell death in several human hepatoma-derived cell lines; however, the molecular mechanism for this remains unknown. In the present study, several diterpenoids were examined for ability to induce XBP1 splic...

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Publicat a:PLoS One
Autors principals: Iwao, Chieko, Shidoji, Yoshihiro
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506074/
https://ncbi.nlm.nih.gov/pubmed/26186544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132761
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