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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
Cells escape the need for mitogens at a restriction point several hours before entering S phase. The restriction point has been proposed to result from CDK4/6 initiating partial Rb phosphorylation to trigger a bistable switch whereby cyclin E-CDK2 and Rb mutually reinforce each other to induce Rb hy...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189330/ https://ncbi.nlm.nih.gov/pubmed/31543423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.08.020 |
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