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A Precise Cdk Activity Threshold Determines Passage Through the Restriction Point
At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed as a point in G1 after growth factor signaling initiates a positive feedback loop of Cdk activity. However, recent studies cast doubt on this model by claiming R occurs prior to positive feedback activatio...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5790185/ https://ncbi.nlm.nih.gov/pubmed/29351845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.017 |
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