Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein’s C-Terminal Helix

The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by phosphorylation. However, the role of Rb phosphorylation...

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Udgivet i:Mol Cell
Main Authors: Topacio, Benjamin R., Zatulovskiy, Evgeny, Cristea, Sandra, Xie, Shicong, Tambo, Carrie S., Rubin, Seth M., Sage, Julien, Kõivomägi, Mardo, Skotheim, Jan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800134/
https://ncbi.nlm.nih.gov/pubmed/30982746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.020
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