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Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch
The G1/S transition is a crucial decision point in the cell cycle. At G1/S, there is an abrupt switch from a state of high cyclin-dependent kinases (CDK) inhibitor (CKI) levels and low S-phase CDK activity to a state of high S-phase CDK activity and degraded CKI. In budding yeast, this transition is...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Frontiers Media S.A.
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3515773/ https://ncbi.nlm.nih.gov/pubmed/23230424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00459 |
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