Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch

The G1/S transition is a crucial decision point in the cell cycle. At G1/S, there is an abrupt switch from a state of high cyclin-dependent kinases (CDK) inhibitor (CKI) levels and low S-phase CDK activity to a state of high S-phase CDK activity and degraded CKI. In budding yeast, this transition is...

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Bibliographic Details
Main Authors: Venta, Rainis, Valk, Ervin, Kõivomägi, Mardo, Loog, Mart
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2012
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3515773/
https://ncbi.nlm.nih.gov/pubmed/23230424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00459
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