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Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle

Cyclin-dependent kinases (CDKs) coordinate hundreds of molecular events during the cell cycle. Multiple cyclins are involved, but the global role of cyclin-specific phosphorylation has remained unsolved. We uncovered a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mi...

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Bibliografische gegevens
Gepubliceerd in:Mol Cell
Hoofdauteurs: Örd, Mihkel, Venta, Rainis, Möll, Kaidi, Valk, Ervin, Loog, Mart
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620034/
https://ncbi.nlm.nih.gov/pubmed/31101497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.04.026
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