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A Precise Cdk Activity Threshold Determines Passage Through the Restriction Point

At the restriction point (R), mammalian cells irreversibly commit to divide. R has been viewed as a point in G1 after growth factor signaling initiates a positive feedback loop of Cdk activity. However, recent studies cast doubt on this model by claiming R occurs prior to positive feedback activatio...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Schwarz, Clayton, Johnson, Amy, Kõivomägi, Mardo, Zatulovskiy, Evgeny, Kravitz, Carolyn J., Doncic, Andreas, Skotheim, Jan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790185/
https://ncbi.nlm.nih.gov/pubmed/29351845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.017
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