A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter

Lipoprotein(a) [Lp(a)] is a major cardiovascular risk factor, which is largely genetically determined by one major gene locus, the LPA gene. Many aspects of the transcriptional regulation of LPA are poorly understood and the role of epigenetics has not been addressed yet. Therefore, we conducted an...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Coassin, Stefan, Hermann-Kleiter, Natascha, Haun, Margot, Wahl, Simone, Wilson, Rory, Paulweber, Bernhard, Kunze, Sonja, Meitinger, Thomas, Strauch, Konstantin, Peters, Annette, Waldenberger, Melanie, Kronenberg, Florian, Lamina, Claudia
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188291/
https://ncbi.nlm.nih.gov/pubmed/32343731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232073
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