A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction

AIMS: Lp(a) concentrations represent a major cardiovascular risk factor and are almost entirely controlled by one single locus (LPA). However, many genetic factors in LPA governing the enormous variance of Lp(a) levels are still unknown. Since up to 70% of the LPA coding sequence are located in a di...

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Vydáno v:Eur Heart J
Hlavní autoři: Coassin, Stefan, Erhart, Gertraud, Weissensteiner, Hansi, Eca Guimarães de Araújo, Mariana, Lamina, Claudia, Schönherr, Sebastian, Forer, Lukas, Haun, Margot, Losso, Jamie Lee, Köttgen, Anna, Schmidt, Konrad, Utermann, Gerd, Peters, Annette, Gieger, Christian, Strauch, Konstantin, Finkenstedt, Armin, Bale, Reto, Zoller, Heinz, Paulweber, Bernhard, Eckardt, Kai-Uwe, Hüttenhofer, Alexander, Huber, Lukas A., Kronenberg, Florian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Fast Track Clinical Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837733/
https://ncbi.nlm.nih.gov/pubmed/28444229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehx174
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