Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis

Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Gu, Yiyou, Singh, Shakti, Alqarihi, Abdullah, Shaw, Karen Joy, Ibrahim, Ashraf S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187618/
https://ncbi.nlm.nih.gov/pubmed/31685475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01966-19
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