726. APX001 (Fosmanogepix) Is Effective in an Immunosuppressed Mouse Model of Rhizopus oryzae Infection

BACKGROUND: Mucormycosis is a life-threatening infection that predominantly occurs in immunocompromised hosts. The antifungal APX001A (manogepix) inhibits Gwt1, an enzyme required for the conserved glycosylphosphatidyl inositol (GPI) post-translational modification in eukaryotes. We previously repor...

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Udgivet i:Open Forum Infect Dis
Main Authors: Gebremariam, Teklegiorgis, Alkhazraji, Sondus, Gu, Yiyou, Alqarihi, Abdullah, Mamouei, Zeinab, Shaw, Karen J, Ibrahim, Ashraf S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810953/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.794
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