A Trans-Specific Polymorphism in ZC3HAV1 Is Maintained by Long-Standing Balancing Selection and May Confer Susceptibility to Multiple Sclerosis

The human ZC3HAV1 gene encodes an antiviral protein. The longest splicing isoform of ZC3HAV1 contains a C-terminal PARP-like domain, which has evolved under positive selection in primates. We analyzed the evolutionary history of this same domain in humans and in Pan troglodytes. We identified two va...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Biol Evol
Auteurs principaux: Cagliani, R., Guerini, F. R., Fumagalli, M., Riva, S., Agliardi, C., Galimberti, D., Pozzoli, U., Goris, A., Dubois, B., Fenoglio, C., Forni, D., Sanna, S., Zara, I., Pitzalis, M., Zoledziewska, M., Cucca, F., Marini, F., Comi, G. P., Scarpini, E., Bresolin, N., Clerici, M., Sironi, M.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187542/
https://ncbi.nlm.nih.gov/pubmed/22319148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss002
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires