Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving

BACKGROUND: Several susceptibility genetic variants for autoimmune diseases have been identified. A subset of these polymorphisms displays an opposite risk profile in different autoimmune conditions. This observation open interesting questions on the evolutionary forces shaping the frequency of thes...

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Autores principales: Cagliani, Rachele, Riva, Stefania, Pozzoli, Uberto, Fumagalli, Matteo, Comi, Giacomo P, Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141431/
https://ncbi.nlm.nih.gov/pubmed/21682861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-11-171
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