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Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving

BACKGROUND: Several susceptibility genetic variants for autoimmune diseases have been identified. A subset of these polymorphisms displays an opposite risk profile in different autoimmune conditions. This observation open interesting questions on the evolutionary forces shaping the frequency of thes...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Cagliani, Rachele, Riva, Stefania, Pozzoli, Uberto, Fumagalli, Matteo, Comi, Giacomo P, Bresolin, Nereo, Clerici, Mario, Sironi, Manuela
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141431/
https://ncbi.nlm.nih.gov/pubmed/21682861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-11-171
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