Cargando...

A Trans-Specific Polymorphism in ZC3HAV1 Is Maintained by Long-Standing Balancing Selection and May Confer Susceptibility to Multiple Sclerosis

The human ZC3HAV1 gene encodes an antiviral protein. The longest splicing isoform of ZC3HAV1 contains a C-terminal PARP-like domain, which has evolved under positive selection in primates. We analyzed the evolutionary history of this same domain in humans and in Pan troglodytes. We identified two va...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Mol Biol Evol
Main Authors: Cagliani, R., Guerini, F. R., Fumagalli, M., Riva, S., Agliardi, C., Galimberti, D., Pozzoli, U., Goris, A., Dubois, B., Fenoglio, C., Forni, D., Sanna, S., Zara, I., Pitzalis, M., Zoledziewska, M., Cucca, F., Marini, F., Comi, G. P., Scarpini, E., Bresolin, N., Clerici, M., Sironi, M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187542/
https://ncbi.nlm.nih.gov/pubmed/22319148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss002
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!