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Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability
Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable, with T(50) values of ∼30–40 °C. Reconstructed ancestral cytochrome P450 enzymes tend t...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7186169/ https://ncbi.nlm.nih.gov/pubmed/32156703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010727 |
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