Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation

Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrP(C), into a pathogenic conformer, PrP(Sc). Infectious prions can exist as different strains, composed of unique conformations of PrP(Sc) that generate strain-specific biological traits, including distinctive patterns of P...

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Udgivet i:PLoS Pathog
Main Authors: Burke, Cassandra M., Walsh, Daniel J., Mark, Kenneth M. K., Deleault, Nathan R., Nishina, Koren A., Agrimi, Umberto, Di Bari, Michele A., Supattapone, Surachai
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185723/
https://ncbi.nlm.nih.gov/pubmed/32294141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008495
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