Efficient Estimation and Applications of Cross-Validated Genetic Predictions to Polygenic Risk Scores and Linear Mixed Models

Large-scale cohorts with combined genetic and phenotypic data, coupled with methodological advances, have produced increasingly accurate genetic predictors of complex human phenotypes called polygenic risk scores (PRSs). In addition to the potential translational impacts of identifying at-risk indiv...

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Detalhes bibliográficos
Publicado no:J Comput Biol
Main Authors: Mefford, Joel, Park, Danny, Zheng, Zhili, Ko, Arthur, Ala-Korpela, Mika, Laakso, Markku, Pajukanta, Päivi, Yang, Jian, Witte, John, Zaitlen, Noah
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185352/
https://ncbi.nlm.nih.gov/pubmed/32077750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2019.0325
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