PTEN inhibitor VO-OHpic suppresses TSC2(-)(/)(-) MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway

Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant disease which involves multiple organs, including the brain, kidney, lung, skin and heart. Renal angiomyolipomas (RAML) are the main causes of mortality in patients with TSC. The preferred treatment for RAML is the use of mTOR...

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Bibliographic Details
Published in:Exp Ther Med
Main Authors: Wang, Wenda, Wang, Xu, Guo, Hao, Cai, Yi, Zhang, Yushi, Li, Hanzhong
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185083/
https://ncbi.nlm.nih.gov/pubmed/32346419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.8629
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