Uric acid priming in human monocytes is driven by the AKT–PRAS40 autophagy pathway

Metabolic triggers are important inducers of the inflammatory processes in gout. Whereas the high serum urate levels observed in patients with gout predispose them to the formation of monosodium urate (MSU) crystals, soluble urate also primes for inflammatory signals in cells responding to gout-rela...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Crişan, Tania O., Cleophas, Maartje C. P., Novakovic, Boris, Erler, Kathrin, van de Veerdonk, Frank L., Stunnenberg, Hendrik G., Netea, Mihai G., Dinarello, Charles A., Joosten, Leo A. B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448210/
https://ncbi.nlm.nih.gov/pubmed/28484006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620910114
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