Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and elevated cytoplasmic HuR correlates with high-grade tumors and poor clinical outcome of breast cancer. HuR promotes tumorig...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Wu, Xiaoqing, Gardashova, Gulhumay, Lan, Lan, Han, Shuang, Zhong, Cuncong, Marquez, Rebecca T., Wei, Lanjing, Wood, Spencer, Roy, Sudeshna, Gowthaman, Ragul, Karanicolas, John, Gao, Fei P., Dixon, Dan A., Welch, Danny R., Li, Ling, Ji, Min, Aubé, Jeffrey, Xu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181695/
https://ncbi.nlm.nih.gov/pubmed/32332873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0933-1
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