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Design, Synthesis and Characterization of a New Series of Fluorescent Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulators

In recent years, new drug discovery approaches based on novel pharmacological concepts have emerged. Allosteric modulators, for example, target receptors at sites other than the orthosteric binding sites and can modulate agonist-mediated activation. Interestingly, allosteric regulation may allow a f...

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Vydáno v:Molecules
Hlavní autoři: Fernández-Dueñas, Víctor, Qian, Mingcheng, Argerich, Josep, Amaral, Carolina, Risseeuw, Martijn D.P., Van Calenbergh, Serge, Ciruela, Francisco
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7180738/
https://ncbi.nlm.nih.gov/pubmed/32230915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25071532
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