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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators as Novel Tools for in Vivo Investigation

[Image: see text] Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have shown promising results in preclinical models for anxiety and drug abuse. Here, we describe a series of aryl-substituted alkynyl analogues of the prototypic mGluR5 NAM 2-methyl-6-(pheny...

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Bibliografiska uppgifter
Huvudupphovsmän: Keck, Thomas M., Zou, Mu-Fa, Zhang, Peng, Rutledge, Rebecca P., Newman, Amy Hauck
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2012
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424002/
https://ncbi.nlm.nih.gov/pubmed/22924094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000726
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