Novel Endochin-Like Quinolones Exhibit Potent In Vitro Activity against Plasmodium knowlesi but Do Not Synergize with Proguanil

Quinolones, such as the antimalarial atovaquone, are inhibitors of the malarial mitochondrial cytochrome bc(1) complex, a target critical to the survival of both liver- and blood-stage parasites, making these drugs useful as both prophylaxis and treatment. Recently, several derivatives of endochin h...

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Publicado en:Antimicrob Agents Chemother
Autores principales: van Schalkwyk, Donelly A., Riscoe, Michael K., Pou, Sovitj, Winter, Rolf W., Nilsen, Aaron, Duffey, Maëlle, Moon, Robert W., Sutherland, Colin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Susceptibility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179610/
https://ncbi.nlm.nih.gov/pubmed/32094134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02549-19
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