Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas

Mutations in isocitrate dehydrogenase (IDH) genes occur in multiple cancer types, lead to global changes in the epigenome, and drive tumorigenesis. Yet, effective strategies targeting solid tumors harboring IDH mutations remain elusive. Here, we demonstrate that IDH-mutant gliomas and cholangiocarci...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Adv
Egile Nagusiak: Wang, Yuxiang, Wild, Aaron T., Turcan, Sevin, Wu, Wei H., Sigel, Carlie, Klimstra, David S., Ma, Xiaoxiao, Gong, Yongxing, Holland, Eric C., Huse, Jason T., Chan, Timothy A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7176409/
https://ncbi.nlm.nih.gov/pubmed/32494639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz3221
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak