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Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas
Targeting the epigenome has been considered a compelling treatment modality for several cancers, including gliomas. Nearly 80% of the lower-grade gliomas and secondary glioblastomas harbor recurrent mutations in isocitrate dehydrogenase (IDH). Mutant IDH generates high levels of 2-hydroxyglutarate (...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6826741/ https://ncbi.nlm.nih.gov/pubmed/31652645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101616 |
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